An arrayed collection of siRNA reagents for RNAi screening, targeting mouse enzymes involved in epigenetic regulation. ON-TARGETplus siRNA is guaranteed to silence, and is modified to reduce off-targets for fewer false positives.
Patented dual-strand ON-TARGETplus modification pattern on all siRNAs to reduce off-targets Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake
Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity
Available as SMARTpool siRNA reagents or a Set of 4 siRNAs in 96-well plates
Guaranteed target gene knockdown
Highlights
Six ready-to-use 96-well plate sets provided for two triplicate screens
Pre-plated, validated RNAi controls included
No aliquoting necessary, just resuspend and add cells
siRNA reagents provided in clear plates at 6.25 pmol per well (50 nM final screening concentration)
Black or white clear-bottom plates available to support assays involving fluorescent or luminescent detection
Caracteristicas
siRNA designed and modified for greater specificity